TBK1/IKK(epsilon)-IN-2

• CAT Number: I013863
• CAS Number: 1292310-49-6
• Molecular Formula: C₂₆H₂₇N₅O₃
• Molecular Weight: 457.52
• Purity: ≥95%
• Target: IKK
• Solubility: DMSO: 21.5 mg/mL
• IUPAC Name: 5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-2-(oxan-4-yloxy)benzonitrile
• InChI: InChI=1S/C26H27N5O3/c27-18-20-17-19(1-6-25(20)34-23-8-13-32-14-9-23)24-7-10-28-26(30-24)29-21-2-4-22(5-3-21)31-11-15-33-16-12-31/h1-7,10,17,23H,8-9,11-16H2,(H,28,29,30)
• InChIKey: BWABTWGSXHTHCG-UHFFFAOYSA-N
• SMILES: C1COCCC1OC2=C(C=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5)C#N

TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.

Reference

[1]. Muvaffak A, et al. Evaluating TBK1 as a therapeutic target in cancers with activated IRF3. Mol Cancer Res. 2014 Jul;12(7):1055-66.