TC-2153

• CAT Number: I037041
• CAS Number: 1381769-23-8
• Molecular Formula: C7H5ClF3NS5
• Molecular Weight: 355.89
• Purity: ≥95%
• Synonyms: 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine;hydrochloride
• InChI: InChI=1S/C7H4F3NS5.ClH/c8-7(9,10)3-1-4(11)6-5(2-3)12-14-16-15-13-6;/h1-2H,11H2;1H
• InChIKey: PYFSCYSDPQMEGZ-UHFFFAOYSA-N
• SMILES: C1=C(C=C2C(=C1N)SSSSS2)C(F)(F)F.Cl

TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor (BDNF) in the brain. And it decreases MAOA and 5-HT1A receptors mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor-mediated signaling[1].
TC-2153 (10 μM; 3 h) decreases the percentage of DOI (HY-103124)-induced c-fos positive neurons in cortical and hippocampal neurons cultured in vitro[1].
Chronic TC-2153 treatment: TC-2153 (20 mg/kg; i.p.; once daily for 7 d) shows antidepressant-like effect without altering locomotor, exploratory activity and anxiety[1].
Acute TC-2153 treatment: TC-2153 (10 mg/kg and 20 mg/kg; p.o.; single dose) inhibits the functional activity of 5-HT2A receptors in vivo in mice[1].

Reference

[1]. Walters JM, et al. Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity. Epilepsia. 2022 May;63(5):1211-1224.
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