TC-DAPK 6

• CAT Number: I003122
• CAS Number: 315694-89-4
• Molecular Formula: C17H12N2O2
• Molecular Weight: 276.29
• Purity: ≥95%
• Synonyms: (4E)-2-[(E)-2-phenylethenyl]-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one
• Target: DAPK
• Solubility: Soluble to 50 mM in DMSO
• Storage: Store at -20°C
• IC50: 69 nM (DAPK1); 225 nM (DAPK3)
• InChI: InChI=1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H/b9-8+,15-11+
• InChIKey: GFGMISOSPOPSHN-QCTDOKRBSA-N
• SMILES: C1=CC=C(C=C1)/C=C/C2=N/C(=C/C3=CN=CC=C3)/C(=O)O2

TC-DAPK 6(CAT: I003122) is a potent and selective inhibitor of death-associated protein kinase 1 (DAPK1), a serine/threonine kinase involved in regulating apoptosis, autophagy, and cellular stress responses. Overactivation of DAPK1 is associated with various neurodegenerative diseases, including Alzheimer’s disease and stroke, due to its role in promoting neuronal cell death. By inhibiting DAPK1 activity, TC-DAPK 6 offers neuroprotective effects, making it a valuable tool in neuroscience research for studying mechanisms of neuronal survival and exploring therapeutic strategies for neurodegenerative disorders and ischemic injuries.