For research use only. Not for therapeutic Use.
TC-O9311(CAT: I009725) is a potent and noteworthy compound characterized by its ability to activate GPR139, a G-protein coupled receptor. As a GPR139 agonist, TC-O9311 exerts its effects by binding to and activating this receptor, thereby triggering intracellular signaling pathways and influencing downstream cellular responses. GPR139 has been implicated in various physiological processes, making TC-O9311 a valuable tool for exploring and understanding the role of GPR139 in these contexts.
| Catalog Number | I009725 |
| CAS Number | 444932-31-4 |
| Synonyms | TC-O 9311; TC-O-9311; TC-O9311; TCO 9311; TCO-9311; TCO9311.;3,5-dimethoxy-benzoic acid, 2-[(1-naphthalenylamino)carbonyl]hydrazide |
| Molecular Formula | C20H19N3O4 |
| Purity | ≥95% |
| Target | Orphan 7-TM Receptors |
| Solubility | Soluble in DMSO |
| Storage | Store at 4 °C |
| IUPAC Name | 1-[(3,5-dimethoxybenzoyl)amino]-3-naphthalen-1-ylurea |
| InChI | InChI=1S/C20H19N3O4/c1-26-15-10-14(11-16(12-15)27-2)19(24)22-23-20(25)21-18-9-5-7-13-6-3-4-8-17(13)18/h3-12H,1-2H3,(H,22,24)(H2,21,23,25) |
| InChIKey | KPTMSQHTGZMEFU-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CC(=C1)C(=O)NNC(=O)NC2=CC=CC3=CC=CC=C32)OC |
| Reference | </br>1: Shi F, Shen JK, Chen D, Fog K, Thirstrup K, Hentzer M, Karlsson JJ, Menon V, Jones KA, Smith KE, Smith G. Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139. ACS Med Chem Lett. 2011 Feb 28;2(4):303-6. doi: 10.1021/ml100293q. eCollection 2011 Apr 14. PubMed PMID: 24900311; PubMed Central PMCID: PMC4028000. |
