TC-S 7006

• CAT Number: I010691
• CAS Number: 871307-18-5
• Molecular Formula: C21H14ClFN6
• Molecular Weight: 404.833
• Purity: ≥95%
• Synonyms: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
• Target: MAP3K
• Solubility: Soluble to 100 mM in DMSO
• Storage: Store at -20C
• IUPAC Name: 4-(3-chloro-4-fluoroanilino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile
• InChI: InChI=1S/C21H14ClFN6/c22-17-6-15(3-4-18(17)23)29-21-14(8-24)11-26-19-12-28-20(7-16(19)21)27-10-13-2-1-5-25-9-13/h1-7,9,11-12H,10H2,(H,26,29)(H,27,28)
• InChIKey: NMEUKWOOQOHUNA-UHFFFAOYSA-N
• SMILES: C1=CC(=CN=C1)CNC2=NC=C3C(=C2)C(=C(C=N3)C#N)NC4=CC(=C(C=C4)F)Cl

TC-S 7006 (Cat.No:I010691) is a potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 50 nM). Selective for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. Inhibits LPS-induced TNF-α secretion from monocytes and attenuates acute myeloid leukemia (AML) cell proliferation in vitro. Also reduces cytolytic activity of human CD8+ cytotoxic T lymphocytes. Cell permeable.