For research use only. Not for therapeutic Use.
TC11 is a MCL1 degrader. TC11 is also a Caspase-9 and CDK1 activator. TC11 structurally relates to immunomodulatory agents as phenylphthalimide derivative. TC11 induces apoptotic death caused by degradation of MCL1 during prolonged mitotic arrest[1][2].
TC11 (0~30 μM; 24 hours; KMS34 cells) induces cell death in KMS34[1].
TC11 (5 μM; 0~48 hours; KMS34 cells) induces cell death occurs through an apoptotic pathway and downregulates MCL1 expression[1].
TC11 (5 μM; 24 hours; KMS34 cells) induces M arrest[1].
| Catalog Number | I045490 |
| CAS Number | 100823-03-8 |
| Synonyms | 5-amino-2-[2,6-di(propan-2-yl)phenyl]isoindole-1,3-dione |
| Molecular Formula | C20H22N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H22N2O2/c1-11(2)14-6-5-7-15(12(3)4)18(14)22-19(23)16-9-8-13(21)10-17(16)20(22)24/h5-12H,21H2,1-4H3 |
| InChIKey | NRPIRIUWEKTNGQ-UHFFFAOYSA-N |
| SMILES | CC(C)C1=C(C(=CC=C1)C(C)C)N2C(=O)C3=C(C2=O)C=C(C=C3)N |
| Reference | [1]. Ichikawa D, et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells. Biochem Biophys Res Commun. 2020;521(1):252-258. [2]. Shiheido H, et al. A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma. PLoS One. 2012;7(6):e38878. |
