For research use only. Not for therapeutic Use.
TC13172（Cat No.:I009671） is a potent inhibitor of mixed lineage kinase domain-like protein (MLKL), a key regulator of programmed necrosis. With its high potency in the single nanomolar range, TC13172 represents a valuable tool for studying the biological function of MLKL. This compound supports the notion that MLKL is a druggable target, suggesting its potential therapeutic significance. By inhibiting MLKL, TC13172 can shed light on the mechanisms and pathways associated with programmed necrosis and contribute to the development of novel treatments for related diseases and conditions.
| Catalog Number | I009671 |
| CAS Number | 2093393-05-4 |
| Synonyms | TC13172; TC 13172; TC-13172.;3-(3-(3-hydroxyphenyl)prop-2-yn-1-yl)-1,7-dimethyl-8-(methylsulfonyl)-3,4,5,7-tetrahydro-1H-purine-2,6-dione |
| Molecular Formula | C17H16N4O5S |
| Purity | ≥95% |
| Target | Mixed Lineage Kinase |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 3-[3-(3-hydroxyphenyl)prop-2-ynyl]-1,7-dimethyl-8-methylsulfonylpurine-2,6-dione |
| InChI | InChI=1S/C17H16N4O5S/c1-19-13-14(18-16(19)27(3,25)26)21(17(24)20(2)15(13)23)9-5-7-11-6-4-8-12(22)10-11/h4,6,8,10,22H,9H2,1-3H3 |
| InChIKey | MCGQDULPSMRNTM-UHFFFAOYSA-N |
| SMILES | CN1C2=C(N=C1S(=O)(=O)C)N(C(=O)N(C2=O)C)CC#CC3=CC(=CC=C3)O |
| Reference | <br /> |
