For research use only. Not for therapeutic Use.
TCMDC-135051 (Cat.No:I018089) is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 has antiparasiticidal activity (EC50=320 nM)[1].<br>TCMDC-135051 shows potent activity against P. berghei sporozoites in a liver invasion and development assay in which the compound shows a pEC50 value of 6.17 (EC50=0.40 μM).
| Catalog Number | I018089 |
| CAS Number | 2413716-15-9 |
| Molecular Formula | C₂₉H₃₃N₃O₃ |
| Purity | ≥95% |
| Reference | [1]. Alam MM, et al. Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science. 2019 Aug 30;365(6456). pii: eaau1682. |
