TCO-OH

• CAT Number: I016604
• CAS Number: 85081-69-2
• Molecular Formula: C₈H₁₄O
• Molecular Weight: 126.2
• Purity: ≥95%
• Target: PROTAC Linkers
• Storage: -20°C
• IUPAC Name: (4Z)-cyclooct-4-en-1-ol
• InChI: InChI=1S/C8H14O/c9-8-6-4-2-1-3-5-7-8/h1-2,8-9H,3-7H2/b2-1-
• InChIKey: UCPDHOTYYDHPEN-UPHRSURJSA-N
• SMILES: C1CC=CCCC(C1)O

TCO-OH（Cat No.:I016604） is an alkyl chain-based linker commonly used in the synthesis of proteolysis-targeting chimera (PROTAC) molecules. TCO-OH contains a terminal alkyne group, which enables bioorthogonal click chemistry reactions with tetrazine-functionalized molecules. This linker allows for the conjugation of target protein binders, such as small molecules or antibodies, to E3 ligase ligands, facilitating the targeted degradation of specific proteins. TCO-OH provides versatility in the design and construction of PROTACs, enhancing their potential as therapeutic agents for the treatment of various diseases.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.