TCO-PEG2-amine

• CAT Number: I016613
• CAS Number: 2141981-87-3
• Molecular Formula: C15H28N2O4
• Molecular Weight: 300.39
• Purity: ≥95%
• Synonyms: [(4Z)-cyclooct-4-en-1-yl] N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]carbamate
• InChI: InChI=1S/C15H28N2O4/c16-8-10-19-12-13-20-11-9-17-15(18)21-14-6-4-2-1-3-5-7-14/h1-2,14H,3-13,16H2,(H,17,18)/b2-1-
• InChIKey: XCPPYCGUCZZMQS-UPHRSURJSA-N
• SMILES: C1CC=CCCC(C1)OC(=O)NCCOCCOCCN

TCO-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Reference

[1]. Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.
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