TCO-PEG4-NHS ester

• CAT Number: I016621
• CAS Number: 1613439-69-2
• Molecular Formula: C₂₄H₃₈N₂O₁₀
• Molecular Weight: 514.57
• Purity: ≥95%
• Target: PROTAC

TCO-PEG4-NHS ester (CAT: I016621) is a derivative of TCO (trans-cyclooctene) modified with a polyethylene glycol (PEG) linker and an N-hydroxysuccinimide (NHS) ester functional group. It is commonly used as a bioconjugation reagent for the modification of biomolecules. The NHS ester group allows for the covalent attachment of TCO-PEG4 to primary amine groups on target molecules, such as proteins or peptides, through amide bond formation. The PEG linker enhances solubility and flexibility, while TCO enables bioorthogonal click chemistry reactions with tetrazine-modified molecules. This versatile compound facilitates the conjugation of TCO-PEG4 to various biomolecules for applications in drug delivery, imaging, and diagnostics.

Reference

[1]. Jung S, et al. An integrated approach for enhanced protein conjugation and capture with viral nanotemplatesand hydrogel microparticle platforms via rapid bioorthogonal reactions. Langmuir. 2014 Jul 8;30(26):7762-70.