For research use only. Not for therapeutic Use.
TCO-PNB ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016615 |
| CAS Number | 1438415-89-4 |
| Synonyms | [(1R,4E)-cyclooct-4-en-1-yl] (4-nitrophenyl) carbonate |
| Molecular Formula | C15H17NO5 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H17NO5/c17-15(20-13-6-4-2-1-3-5-7-13)21-14-10-8-12(9-11-14)16(18)19/h1-2,8-11,13H,3-7H2/b2-1+/t13-/m0/s1 |
| InChIKey | FJMMADPCDJNXAH-AORQRIRUSA-N |
| SMILES | C1CC=CCCC(C1)OC(=O)OC2=CC=C(C=C2)[N+](=O)[O-] |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
