TCO-PNB Ester

• CAT Number: I037050
• CAS Number: 1354323-64-0
• Molecular Formula: C15H17NO5
• Molecular Weight: 291.31
• Purity: 95%
• Synonyms: TCO-PNB Ester
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: cyclooct-4-en-1-yl (4-nitrophenyl) carbonate
• InChI: InChI=1S/C15H17NO5/c17-15(20-13-6-4-2-1-3-5-7-13)21-14-10-8-12(9-11-14)16(18)19/h1-2,8-11,13H,3-7H2
• InChIKey: FJMMADPCDJNXAH-UHFFFAOYSA-N
• SMILES: C1CC=CCCC(C1)OC(=O)OC2=CC=C(C=C2)[N+](=O)[O-]

TCO-PNB Ester(CAT: I037050) (trans-cyclooctene–para-nitrobenzyl ester) is a specialized bioorthogonal reagent designed for click chemistry applications, particularly in bioconjugation and drug delivery. The TCO (trans-cyclooctene) group enables rapid and selective inverse-electron-demand Diels-Alder (IEDDA) reactions with tetrazines, facilitating efficient, catalyst-free conjugation under mild, physiological conditions. The para-nitrobenzyl (PNB) ester serves as a cleavable linker, allowing for controlled release of attached molecules in response to specific stimuli. TCO-PNB Ester is widely used in chemical biology and therapeutic research for developing targeted drug delivery systems, imaging agents, and precision therapies.