TCO-SS-amine

• CAT Number: I045944
• Molecular Formula: C13H24N2O2S2
• Molecular Weight: 304.47
• Purity: ≥95%
• Synonyms: [(1S,4E)-cyclooct-4-en-1-yl] N-[2-(2-aminoethyldisulfanyl)ethyl]carbamate
• InChI: InChI=1S/C13H24N2O2S2/c14-8-10-18-19-11-9-15-13(16)17-12-6-4-2-1-3-5-7-12/h1-2,12H,3-11,14H2,(H,15,16)/b2-1+/t12-/m1/s1
• InChIKey: OFLXMCDIPGWICF-YYRQZUAOSA-N
• SMILES: C1CC=CCCC(C1)OC(=O)NCCSSCCN

TCO-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. TCO-SS-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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