For research use only. Not for therapeutic Use.
TCPOBOP (Cat No.: R015088)i s an agonist of the constitutive androstane receptor (CAR) (EC50 = 20 nM). TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents. TCPOBOP has been used for enhancing Mcl-1-Italics promoter functions in mouse hepatoma cells. TCPOBOP has also been used to study constitutive androstane receptor(CAR)-induced gene expression in mouse hepatocytes.
| Catalog Number | R015088 |
| CAS Number | 76150-91-9 |
| Synonyms | 1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene; 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene; |
| Molecular Formula | C16H8Cl4N2O2 |
| Purity | ≥95% |
| Target | Bcl-2 Family |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Store at +4℃ |
| IUPAC Name | 3,5-dichloro-2-[4-(3,5-dichloropyridin-2-yl)oxyphenoxy]pyridine |
| InChI | InChI=1S/C16H8Cl4N2O2/c17-9-5-13(19)15(21-7-9)23-11-1-2-12(4-3-11)24-16-14(20)6-10(18)8-22-16/h1-8H |
| InChIKey | BAFKRPOFIYPKBQ-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1OC2=C(C=C(C=N2)Cl)Cl)OC3=C(C=C(C=N3)Cl)Cl |
