T.cruzi-IN-1

• CAT Number: I015597
• CAS Number: 1350920-22-7
• Molecular Formula: C₂₂H₂₅F₃N₂O
• Molecular Weight: 390.44
• Purity: ≥95%
• Target: Parasite
• IUPAC Name: N-benzyl-N-methyl-1-[[4-(trifluoromethyl)phenyl]methyl]piperidine-3-carboxamide
• InChI: InChI=1S/C22H25F3N2O/c1-26(14-17-6-3-2-4-7-17)21(28)19-8-5-13-27(16-19)15-18-9-11-20(12-10-18)22(23,24)25/h2-4,6-7,9-12,19H,5,8,13-16H2,1H3
• InChIKey: UYYRGUHHPKHWTR-UHFFFAOYSA-N
• SMILES: CN(CC1=CC=CC=C1)C(=O)C2CCCN(C2)CC3=CC=C(C=C3)C(F)(F)F

T.cruzi-IN-1（Cat No.:I015597）is a potent inhibitor of Trypanosoma cruzi, the causative agent of Chagas disease. It exhibits an IC₅₀ of 8 nM against the parasite, indicating high efficacy.As a 4-trifluoromethyl substituted analog, T.cruzi-IN-1 has potential therapeutic applications in both acute and chronic stages of Chagas disease. Its mechanism involves disrupting parasite replication, making it a promising candidate for further research and development in antitrypanosomal therapies. The compound’s potency and specificity highlight its significance in the ongoing search for effective treatments against T. cruzi infections.

Reference

[1]. Germain AR, et al. Identification of small-molecule inhibitors of Trypansoma cruzi replication. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7197-200.