TCS 359

• CAT Number: I003049
• CAS Number: 301305-73-7
• Molecular Formula: C18H20N2O4S
• Molecular Weight: 360.4
• Purity: ≥95%
• Synonyms: 2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
• Target: FLT3
• Solubility: DMSO 15 mg/mL; Water <1 mg/mL; Ethanol<1 mg/mL
• Storage: 3 years -20℃ powder
• IC50: 42 nM [1]
• InChI: InChI=1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
• InChIKey: FSPQCTGGIANIJZ-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC

TCS 359 (Cat.No:I003049), a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM. TCS 359 inhibits MV4-11 proliferation with IC50 of 340 nM. TCS 359 is highly selective for FLT3 against a panel of kinases .

Reference

[1]. Patch RJ, et al. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3282-6.