TCS 46b (Compound 46b) is a potent, selective and orally active NMDA NR1A/2B receptor antagonist with an IC50 of 5.3 nM[1]. TCS 46b is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
TCS 46b (Compound 46b; 10 and 30 mg/kg; p.o. or i.p.; once) potentiates the effects of L-DOPA in the 6-OHDA-lesioned rat[1].
| Catalog Number | I010630 |
| CAS Number | 302799-86-6 |
| Synonyms | 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzimidazol-2-one |
| Molecular Formula | C22H23N3O |
| Purity | 95% |
| InChI | InChI=1S/C22H23N3O/c26-22-23-20-9-8-18(16-21(20)24-22)7-4-12-25-13-10-19(11-14-25)15-17-5-2-1-3-6-17/h1-3,5-6,8-9,16,19H,10-15H2,(H2,23,24,26) |
| InChIKey | JJEXWPHPFZLTCU-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1CC2=CC=CC=C2)CC#CC3=CC4=C(C=C3)NC(=O)N4 |
| Reference | [1]. Wright JL, et al. Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines. J Med Chem. 2000 Sep 7;43(18):3408-19. |
