TCS JNK 5a

• CAT Number: I003105
• CAS Number: 312917-14-9
• Molecular Formula: C₂₀H₁₆N₂OS
• Molecular Weight: 332.42
• Purity: ≥95%
• Synonyms: N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
• Target: Apoptosis
• Solubility: DMSO: ≥ 51 mg/mL
• Storage: Room Temperature
• IC50: 6.7/6.5(pIC50, JNK3/JNK2)
• InChI: InChI=1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23)
• InChIKey: WQGDQGAFSDMBLA-UHFFFAOYSA-N
• SMILES: C1CCC2=C(C1)C(=C(S2)NC(=O)C3=CC=CC4=CC=CC=C43)C#N

JNK inhibitor IX（Cat No.:I003105）, also known as TCS JNK 5a, is a potent and highly selective inhibitor of c-Jun N-terminal kinases (JNKs). It exhibits high affinity for JNK2 and JNK3 isoforms with pIC50 values of 6.5 and 6.7, respectively. By inhibiting JNK activity, JNK inhibitor IX disrupts the JNK signaling pathway, which is involved in various cellular processes such as inflammation, apoptosis, and stress response. Its selectivity towards JNK isoforms makes it a valuable tool for studying the specific roles of JNK2 and JNK3 in cellular functions and disease pathways.

Reference

[1]. Angell RM, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1296-301.