For research use only. Not for therapeutic Use.
Orexin receptors R1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCX-OX2-29 is an antagonist of OX2R (pK<sub>i</sub> = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC<sub>50</sub>s = 40 nM and >10,000 nM, respectively). It blocks the inhibitory action of orexin A on forskolin-induced cAMP formation.
| Catalog Number | R065541 |
| CAS Number | 1610882-30-8 |
| Synonyms | (2S)-1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone, monohydrochloride |
| Molecular Formula | C23H31N3O3 • HCl |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| InChI | InChI=1S/C23H31N3O3.ClH/c1-23(2,3)21(25-14-16-6-9-24-10-7-16)22(27)26-11-8-17-12-19(28-4)20(29-5)13-18(17)15-26;/h6-7,9-10,12-13,21,25H,8,11,14-15H2,1-5H3;1H/t21-;/m1./s1 |
| InChIKey | NHKNHFJTMINMBP-ZMBIFBSDSA-N |
| SMILES | COC1=C(OC)C=C(CN(C([C@H](C(C)(C)C)NCC2=CC=NC=C2)=O)CC3)C3=C1.Cl |
| Reference | 1.Mould, R.,Brown, J.,Marshall, F.H., et al. Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. British Journal of Pharmacology 171(2), 351-363 (2014). |
