TD-165

• CAT Number: I017371
• CAS Number: 2305936-56-3
• Molecular Formula: C₄₆H₅₉N₇O₈S
• Molecular Weight: 870.07
• Purity: ≥95%
• Target: PROTACs
• IUPAC Name: (2S,4R)-1-[(2S)-2-[11-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]undecanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C46H59N7O8S/c1-28-39(62-27-49-28)30-19-17-29(18-20-30)25-48-41(57)35-24-31(54)26-52(35)45(61)40(46(2,3)4)50-36(55)16-11-9-7-5-6-8-10-12-23-47-33-15-13-14-32-38(33)44(60)53(43(32)59)34-21-22-37(56)51-42(34)58/h13-15,17-20,27,31,34-35,40,47,54H,5-12,16,21-26H2,1-4H3,(H,48,57)(H,50,55)(H,51,56,58)/t31-,34?,35+,40-/m1/s1
• InChIKey: KSXVXTSIDVRZBR-IINAPWRYSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCCCNC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O)O

TD-165(CAT: I017371) is a PROTAC-based degrader specifically targeting cereblon (CRBN), widely utilized in protein degradation and drug discovery research. It is designed with a CRBN ligand binding group, a linker, and a von Hippel-Landau (VHL) binding group to facilitate proteasomal degradation of CRBN. TD-165 exhibits a DC₅₀ of 20.4 nM and a maximum degradation (Dmax) of 99.6% after 24 hours. In HEK293T cells, it induces a concentration-dependent reduction of CRBN levels within the range of 0.1–10 μM. Its high efficacy and specificity make TD-165 an essential tool for preclinical studies exploring targeted protein degradation and therapeutic applications of PROTAC technology.