TDP1 Inhibitor-2

• CAT Number: I043507
• CAS Number: 859142-95-3
• Molecular Formula: C25H14Cl2O5
• Molecular Weight: 465.28
• Purity: ≥95%
• Synonyms: 7-[(2,6-dichlorophenyl)methoxy]-4-(2-oxochromen-3-yl)chromen-2-one
• InChI: InChI=1S/C25H14Cl2O5/c26-20-5-3-6-21(27)19(20)13-30-15-8-9-16-17(12-24(28)31-23(16)11-15)18-10-14-4-1-2-7-22(14)32-25(18)29/h1-12H,13H2
• InChIKey: QEOYHBDGERTIQV-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C=C(C(=O)O2)C3=CC(=O)OC4=C3C=CC(=C4)OCC5=C(C=CC=C5Cl)Cl

TDP1 Inhibitor-2（Cat No.:I043507）is a small-molecule compound designed to target and inhibit the enzyme tyrosyl-DNA phosphodiesterase 1 (TDP1), which plays a key role in repairing DNA damage caused by topoisomerase I inhibitors and other genotoxic stressors. By inhibiting TDP1, TDP1 Inhibitor-2 sensitizes cancer cells to DNA-damaging treatments, making it a potential adjunct in cancer therapy. It has shown promise in enhancing the efficacy of chemotherapeutic agents, particularly in tumors resistant to standard treatments. Ongoing research focuses on evaluating its safety, efficacy, and potential in combination therapies for cancer treatment.