For research use only. Not for therapeutic Use.
TEAD inhibitor TM2 is a potent reversible pan-TEAD inhibitor with strong modulation of TEAD-YAP/TAZ transcriptional activities. TM2 exhibits strong inhibition of TEAD2 and TEAD4 auto-palmitoylation with IC50 values of 156 nM and 38 nM, respectively. Also, TM2 significantly inhibits YAP-dependent liver organoid growth ex vivo and inhibits proliferation of YAP-dependent cancer cells as a single agent or in combination with a MEK inhibitor.
KEYWORDS: TEAD inhibitor TM2 | Supplier | TEAD inhibitor | TM 2 | TM-2 | CAS [1008768-41-9] | Hippo signaling pathway | YAP | Inhibitor | Transcription Factors | TEAD-YAP
| Catalog Number | I047700 |
| CAS Number | 1008768-41-9 |
| Molecular Formula | C26H33N3O3 |
| Purity | ≥95% |
| IUPAC Name | 4-[3-(2-cyclohexylethoxy)benzoyl]-N-phenylpiperazine-1-carboxamide |
| InChI | InChI=1S/C26H33N3O3/c30-25(22-10-7-13-24(20-22)32-19-14-21-8-3-1-4-9-21)28-15-17-29(18-16-28)26(31)27-23-11-5-2-6-12-23/h2,5-7,10-13,20-21H,1,3-4,8-9,14-19H2,(H,27,31) |
| SMILES | C1CCC(CC1)CCOC2=CC=CC(=C2)C(=O)N3CCN(CC3)C(=O)NC4=CC=CC=C4 |
| Reference | L Hu et al. Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode. Elife. 2022 Nov 18;11:e80210. |
