Tebipenem

• CAT Number: I002067
• CAS Number: 161715-21-5
• Molecular Formula: C16H21N3O4S2
• Molecular Weight: 383.49
• Purity: ≥95%
• Synonyms: LJC-11036
• Target: Bacterial
• Solubility: DMSO: ≥ 45 mg/mL, H2O: ≥ 6.2 mg/mL
• Storage: Store at -20°C
• IUPAC Name: (4R,5S,6S)-3-[1-(4,5-dihydro-1,3-thiazol-2-yl)azetidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
• InChI: InChI=1S/C16H21N3O4S2/c1-7-11-10(8(2)20)14(21)19(11)12(15(22)23)13(7)25-9-5-18(6-9)16-17-3-4-24-16/h7-11,20H,3-6H2,1-2H3,(H,22,23)/t7-,8-,10-,11-/m1/s1
• InChIKey: GXXLUDOKHXEFBQ-YJFSRANCSA-N
• SMILES: C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1SC3CN(C3)C4=NCCS4)C(=O)O)[C@@H](C)O

Tebipenem（Cat No.:I002067）is an orally bioavailable carbapenem antibiotic effective against a range of Gram-positive and Gram-negative bacteria, including resistant strains such as MRSA and ESBL-producing organisms. It inhibits bacterial cell wall synthesis, leading to cell death, and is particularly noted for its potential in treating complicated urinary tract infections (cUTIs) and respiratory infections. Tebipenem pivoxil, its prodrug form, enhances its oral absorption, making it the first oral carbapenem option. Widely researched for its role in combating resistant infections, Tebipenem offers a promising addition to antibiotic therapies.

Reference

[1]. Hazra S, et al. Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the β-lactamase from Mycobacterium tuberculosis. Biochemistry. 2014 Jun 10;53(22):3671-8.
[2]. Seenama C, et al. In vitro activity of tebipenem against Burkholderia pseudomallei. Int J Antimicrob Agents. 2013 Oct;42(4):375.