Tebrofen

• CAT Number: I037071
• CAS Number: 27951-69-5
• Molecular Formula: C12H6Br4O4
• Molecular Weight: 533.79
• Purity: 98%
• Synonyms: Tebrofen
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (1,1'-Biphenyl)-2,2',4,4'-tetrol, 3,3',5,5'-tetrabromo-
• InChI: InChI=1S/C12H6Br4O4/c13-5-1-3(9(17)7(15)11(5)19)4-2-6(14)12(20)8(16)10(4)18/h1-2,17-20H
• InChIKey: OCOSYMCDPNAWPA-UHFFFAOYSA-N
• SMILES: OC1=C(Br)C(O)=C(Br)C=C1C2=CC(Br)=C(O)C(Br)=C2O

Tebrofen (Cat No.: I037071) is an antiviral agent primarily used in the treatment of herpes simplex virus (HSV) infections, particularly in ophthalmic applications. It functions by interfering with viral replication, reducing symptoms and viral spread. Tebrofen has been formulated in eye drops and ointments for treating keratoconjunctivitis and other HSV-related ocular conditions. Additionally, it has shown activity against certain DNA viruses, making it useful in dermatological and antiviral research. Its mechanism involves inhibiting viral DNA synthesis, contributing to its therapeutic effectiveness.

Reference

1: Rubelj I, Stepanić V, Jelić D, Vidaček NŠ, Kalajžić AĆ, Ivanković M, Nujić K, Matijašić M, Verbanac D. Tebrophen–an old polyphenol drug with anticancer potential. Molecules. 2012 Jun 28;17(7):7864-86. doi: 10.3390/molecules17077864. PubMed PMID: 22743590.
2: Kogan AI, Bogush PG. [Warts of the feet and their treatment]. Vestn Dermatol Venerol. 1982;(12):55-6. Russian. PubMed PMID: 6297180.
3: Vinogradova TF, Mel’nichenko EM, Maksimova OP, Mikhaĭlovskaia VP. [Viral warts of the oral mucosa in children]. Stomatologiia (Mosk). 1982 Sep-Oct;61(5):63-5. Russian. PubMed PMID: 6293124.
4: Fadeeva NI, Gerasina SF. [Problems of the molecular mechanism of the effects of synthetic antiviral drugs]. Antibiot Khimioter. 1989 Sep;34(9):652-6. Russian. PubMed PMID: 2558620.