For research use only. Not for therapeutic Use.
Tecadenoson (Cat.No:I009735), also known as CVT-510, is an adenosine A1 receptor agonist potentially for the treatment of paroxysmal supraventricular tachycardia. Tecadenoson appears to be an effective agent for producing rapid and sustained conversion of PSVT to sinus rhythm.
| Catalog Number | I009735 |
| CAS Number | 204512-90-3 |
| Synonyms | Tecadenoson; CVT-510; CVT 510; CVT510.;(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(((R)-tetrahydrofuran-3-yl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol |
| Molecular Formula | C14H19N5O5 |
| Purity | ≥95% |
| Target | Adenosine Receptor |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]oxolane-3,4-diol |
| InChI | InChI=1S/C14H19N5O5/c20-3-8-10(21)11(22)14(24-8)19-6-17-9-12(15-5-16-13(9)19)18-7-1-2-23-4-7/h5-8,10-11,14,20-22H,1-4H2,(H,15,16,18)/t7-,8-,10-,11-,14-/m1/s1 |
| InChIKey | OESBDSFYJMDRJY-BAYCTPFLSA-N |
| SMILES | C1COCC1NC2=NC=NC3=C2N=CN3C4C(C(C(O4)CO)O)O |
| Reference | </br>1:Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1. Lepist EI, Damaraju VL, Zhang J, Gati WP, Yao SY, Smith KM, Karpinski E, Young JD, Leung KH, Cass CE.Drug Metab Dispos. 2013 Apr;41(4):916-22. doi: 10.1124/dmd.112.049858. Epub 2013 Feb 6. PMID: 23388705 Free Article</br>2:Tecadenoson: a novel, selective A1 adenosine receptor agonist. Peterman C, Sanoski CA.Cardiol Rev. 2005 Nov-Dec;13(6):315-21. PMID: 16230891 </br>3:Trial to evaluate the management of paroxysmal supraventricular tachycardia during an electrophysiology study with tecadenoson. Ellenbogen KA, O/’Neill G, Prystowsky EN, Camm JA, Meng L, Lieu HD, Jerling M, Shreeniwas R, Belardinelli L, Wolff AA; TEMPEST Study Group..Circulation. 2005 Jun 21;111(24):3202-8. Epub 2005 Jun 13. PMID: 15956124 Free Article</br>4:Termination of paroxysmal supraventricular tachycardia by tecadenoson (CVT-510), a novel A1-adenosine receptor agonist. Prystowsky EN, Niazi I, Curtis AB, Wilber DJ, Bahnson T, Ellenbogen K, Dhala A, Bloomfield DM, Gold M, Kadish A, Fogel RI, Gonzalez MD, Belardinelli L, Shreeniwas R, Wolff AA.J Am Coll Cardiol. 2003 Sep 17;42(6):1098-102. PMID: 13678937 Free Article |
