Tecastemizole

• CAT Number: I037073
• CAS Number: 75970-99-9
• Molecular Formula: C19H21FN4
• Molecular Weight: 324.4
• Purity: 98%
• Synonyms: Tecastemizole; Norastemizole; R 43512; R-43512; R43512; T 1348; T-1348; T1348
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 1-(4-fluorobenzyl)-N-(piperidin-4-yl)-1H-benzo[d]imidazol-2-amine
• InChI: InChI=1S/C19H21FN4/c20-15-7-5-14(6-8-15)13-24-18-4-2-1-3-17(18)23-19(24)22-16-9-11-21-12-10-16/h1-8,16,21H,9-13H2,(H,22,23)
• InChIKey: SFOVDSLXFUGAIV-UHFFFAOYSA-N
• SMILES: FC1=CC=C(CN2C3=CC=CC=C3N=C2NC4CCNCC4)C=C1

Tecastemizole, a major metabolite of astemizole, is a potent and selective H1 receptor antagonist. Evidence suggests that this and certain other H1 receptor antagonists may possess anti-inflammatory effects.

Reference

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