Teclozan

For research use only. Not for therapeutic Use.

  • CAT Number: I037078
  • CAS Number: 5560-78-1
  • Molecular Formula: C20H28Cl4N2O4
  • Molecular Weight: 502.25
  • Purity: 98%
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Teclozan(Cat No.:I037078)is an antiprotozoal medication primarily used for treating infections caused by Entamoeba histolytica, the parasite responsible for amoebiasis. It works by targeting the metabolic processes of the parasite, effectively halting its growth and clearing the infection from the gastrointestinal tract. Known for its high efficacy and tolerability, Teclozan is often prescribed in cases of intestinal amoebiasis, providing a reliable treatment option for both acute and chronic infections. Its minimal side effects make it suitable for prolonged use, contributing to its value in managing amoebic infections in endemic areas.


Catalog Number I037078
CAS Number 5560-78-1
Synonyms

Teclozan; Falmonox; Teclosine; Teclozine; NSC 107433; Teclosan; Teclosine; Win 13146; Win-13146; Win13146; Win-AM 13146;

Molecular Formula C20H28Cl4N2O4
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage 4°C, protect from light
IUPAC Name 2,2-dichloro-N-[[4-[[(2,2-dichloroacetyl)-(2-ethoxyethyl)amino]methyl]phenyl]methyl]-N-(2-ethoxyethyl)acetamide
InChI InChI=1S/C20H28Cl4N2O4/c1-3-29-11-9-25(19(27)17(21)22)13-15-5-7-16(8-6-15)14-26(10-12-30-4-2)20(28)18(23)24/h5-8,17-18H,3-4,9-14H2,1-2H3
InChIKey MSJLJWCAEPENBL-UHFFFAOYSA-N
SMILES CCOCCN(CC1=CC=C(C=C1)CN(CCOCC)C(=O)C(Cl)Cl)C(=O)C(Cl)Cl
Reference

1: Antiamoebic drugs for treating amoebic colitis Maria Liza M Gonzales, Leonila F Dans, Juliet Sio‐Aguilar
Cochrane Database Syst Rev. 2019 Jan; 2019(1): CD006085. Published online 2019 Jan 9. doi: 10.1002/14651858.CD006085.pub3 PMCID: PMC6326239
2: Intestinal parasites. R Knight, M G Schultz, D W Hoskins, P D Marsden Gut. 1973 Feb; 14(2): 145–168. doi: 10.1136/gut.14.2.145 PMCID: PMC1412563
3: Comparative genomics identifies potential virulence factors in Clostridium tertium and C. paraputrificum Marina Muñoz, Daniel Restrepo-Montoya, Nitin Kumar, Gregorio Iraola, Giovanny Herrera, Dora I. Ríos Chaparro, Diana Díaz-Arévalo, Manuel A. Patarroyo, Trevor D. Lawley, Juan David Ramírez Virulence. 2019; 10(1): 657–676. Published online 2019 Jul 13. doi: 10.1080/21505594.2019.1637699 PMCID: PMC6629180
4: Parasite-related diarrhoeas WHO Scientific Working Group Bull World Health Organ. 1980; 58(6): 819–830.
PMCID: PMC2396014
5: Flavonoids as a Natural Treatment Against Entamoeba histolytica Moisés Martínez-Castillo, Judith Pacheco-Yepez, Nadia Flores-Huerta, Paula Guzmán-Téllez, Rosa A. Jarillo-Luna, Luz M. Cárdenas-Jaramillo, Rafael Campos-Rodríguez, Mineko Shibayama Front Cell Infect Microbiol. 2018; 8: 209. Published online 2018 Jun 22. doi: 10.3389/fcimb.2018.00209 PMCID: PMC6024094
6: Availability of essential medicines in primary health care of the Brazilian Unified Health System Renata Cristina Rezende Macedo do Nascimento, Juliana Álvares, Augusto Afonso Guerra, Junior, Isabel Cristina Gomes, Ediná Alves Costa, Silvana Nair Leite, Karen Sarmento Costa, Orlando Mario Soeiro, Ione Aquemi Guibu, Margô Gomes de Oliveira Karnikowski, Francisco de Assis Acurcio Rev Saude Publica. 2017; 51(Suppl 2): 10s.
Published online 2017 Sep 22. doi: 10.11606/S1518-8787.2017051007062 PMCID: PMC5676352

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