Tecovirimat

For research use only. Not for therapeutic Use.

  • CAT Number: I037080
  • CAS Number: 869572-92-9
  • Molecular Formula: C19H15F3N2O3
  • Molecular Weight: 376.33
  • Purity: 98%
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Tecovirimat(Cat No.:I037080)is an antiviral medication approved for the treatment of smallpox and related orthopoxvirus infections, such as monkeypox and cowpox. It works by inhibiting the viral VP37 envelope protein, which is essential for the formation and spread of virus particles within the body. By blocking this protein, Tecovirimat prevents the virus from leaving infected cells, limiting its ability to spread. Tecovirimat offers a vital defense against orthopoxvirus outbreaks, especially in the event of bioterrorism or resurgence, providing an effective and well-tolerated treatment option for smallpox and related diseases.


Catalog Number I037080
CAS Number 869572-92-9
Synonyms

N-[(1S,2S,6R,7R,8R,10S)-3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl]-4-(trifluoromethyl)benzamide

Molecular Formula C19H15F3N2O3
Purity 98%
Target VARV p37
Target Protein

P33815

Appearance Solid
Storage Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
IC50 IC50: 10 nM
IUPAC Name N-[(1S,2S,6R,7R,8R,10S)-3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl]-4-(trifluoromethyl)benzamide
InChI InChI=1S/C19H15F3N2O3/c20-19(21,22)9-3-1-8(2-4-9)16(25)23-24-17(26)14-10-5-6-11(13-7-12(10)13)15(14)18(24)27/h1-6,10-15H,7H2,(H,23,25)/t10-,11+,12+,13-,14-,15+
InChIKey CSKDFZIMJXRJGH-VWLPUNTISA-N
SMILES C1[C@@H]2[C@H]1[C@@H]3C=C[C@H]2[C@@H]4[C@H]3C(=O)N(C4=O)NC(=O)C5=CC=C(C=C5)C(F)(F)F
Reference

[1]. Yang G, et al. An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge. J Virol. 2005 Oct;79(20):13139-49.
[Content Brief]

[2]. Quenelle DC, et al. Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice. Antimicrob Agents Chemother. 2007 Feb;51(2):689-95.
[Content Brief]

[3]. Andrew T Russo, et al. An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications. Expert Rev Anti Infect Ther. 2021 Mar;19(3):331-344.
[Content Brief]

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