Telithromycin

• CAT Number: I002452
• CAS Number: 191114-48-4
• Molecular Formula: C43H65N5O10
• Molecular Weight: 812.00
• Purity: ≥95%
• Synonyms: HMR 3647;Ketek;RU 66647
• Target: Bacterial
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: (1S,2R,5R,7R,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-15-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone
• InChI: InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1
• InChIKey: LJVAJPDWBABPEJ-PNUFFHFMSA-N
• SMILES: CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=C4)C5=CN=CC=C5)C

Telithromycin（Cat No.:I002452）is a ketolide antibiotic derived from erythromycin, designed to treat respiratory infections like community-acquired pneumonia, acute bronchitis, and sinusitis. It works by binding to bacterial ribosomes and inhibiting protein synthesis, effective against certain macrolide-resistant strains, including Streptococcus pneumoniae and Haemophilus influenzae. Known for its potent action against respiratory pathogens, telithromycin addresses bacterial resistance with its enhanced binding affinity. However, its use is limited due to potential side effects, including hepatotoxicity. Telithromycin remains an option in specific cases where standard antibiotics prove ineffective.

Reference

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