Telithromycin

• CAT Number: I002452
• CAS Number: 191114-48-4
• Molecular Formula: C43H65N5O10
• Molecular Weight: 812.00
• Purity: ≥95%
• Synonyms: HMR 3647;Ketek;RU 66647
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: (1S,2R,5R,7R,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-15-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone
• InChI: InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1
• InChIKey: LJVAJPDWBABPEJ-PNUFFHFMSA-N
• SMILES: CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=C4)C5=CN=CC=C5)C

Telithromycin（Cat No.:I002452）is a ketolide antibiotic derived from erythromycin, designed to treat respiratory infections like community-acquired pneumonia, acute bronchitis, and sinusitis. It works by binding to bacterial ribosomes and inhibiting protein synthesis, effective against certain macrolide-resistant strains, including Streptococcus pneumoniae and Haemophilus influenzae. Known for its potent action against respiratory pathogens, telithromycin addresses bacterial resistance with its enhanced binding affinity. However, its use is limited due to potential side effects, including hepatotoxicity. Telithromycin remains an option in specific cases where standard antibiotics prove ineffective.

Reference

1: Nicolau DP. Clinical use of antimicrobial pharmacodynamic profiles to optimise
treatment outcomes in community-acquired bacterial respiratory tract infections:
application to telithromycin. Expert Opin Pharmacother. 2004 Feb;5(2):229-35.
Review. PubMed PMID: 14996620.

2: Lorenz J. Telithromycin: the first ketolide antibacterial for the treatment of
community-acquired respiratory tract infections. Int J Clin Pract. 2003
Jul-Aug;57(6):519-29. Review. PubMed PMID: 12918892.

3: Hammerschlag MR, Roblin PM, Bébéar CM. Activity of telithromycin, a new
ketolide antibacterial, against atypical and intracellular respiratory tract
pathogens. J Antimicrob Chemother. 2001 Sep;48 Suppl T1:25-31. Review. PubMed
PMID: 11566973.

4: Drusano G. Pharmacodynamic and pharmacokinetic considerations in antimicrobial
selection: focus on telithromycin. Clin Microbiol Infect. 2001;7 Suppl 3:24-9.
Review. PubMed PMID: 11523559.

5: Felmingham D. Microbiological profile of telithromycin, the first ketolide
antimicrobial. Clin Microbiol Infect. 2001;7 Suppl 3:2-10. Review. PubMed PMID:
11523558.