For research use only, not for therapeutic use.
Telmisartan（Cat No.:A000384）is an angiotensin II receptor blocker (ARB) used to treat hypertension and reduce cardiovascular risk in patients with conditions like stroke or heart attack. By selectively blocking angiotensin II receptors, Telmisartan relaxes blood vessels, lowering blood pressure and improving blood flow. It is also used to manage conditions such as diabetic nephropathy and heart failure. Telmisartan has a long duration of action, allowing for once-daily dosing, and offers additional benefits in managing metabolic syndrome due to its partial agonism of the peroxisome proliferator-activated receptor gamma (PPAR-γ).
| Catalog Number | A000384 |
| CAS Number | 144701-48-4 |
| Synonyms | 144701-48-4; Micardis; Pritor; BIBR 277; Kinzalmono |
| Molecular Formula | C33H30N4O2 |
| Purity | ≥95% |
| Target | RAAS |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | -20°C |
| IUPAC Name | 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid |
| InChI | InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39) |
| InChIKey | RMMXLENWKUUMAY-UHFFFAOYSA-N |
| SMILES | CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)O)C=C(C=C2C)C5=NC6=CC=CC=C6N5C |
| Reference | 1: Sengupta P, Chatterjee B, Pal TK. Assessment of preclinical pharmacokinetics 2: Li J, Chen H, Zhou Q, Hu L, Ma L, Han H, Li W, Du R, Tian L. Effects of <br> 4: Samukawa E, Fujihara S, Oura K, Iwama H, Yamana Y, Tadokoro T, Chiyo T, <br> <br> 7: Zhang QZ, Liu YL, Wang YR, Fu LN, Zhang J, Wang XR, Wang BM. Effects of <br> 9: Kato Y, Mukai Y, Rane A, Inotsume N, Toda T. The Inhibitory Effect of <br> |
