Teloxantrone

For research use only. Not for therapeutic Use.

  • CAT Number: I009744
  • CAS Number: 91441-48-4
  • Molecular Formula: C21H25N5O4
  • Molecular Weight: 411.462
  • Purity: ≥95%
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Teloxantrone(Cat No.:I009744) is an anthrapyrazole antineoplastic antibiotic. Teloxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair, as well as RNA and protein synthesis.


Catalog Number I009744
CAS Number 91441-48-4
Synonyms

Teloxantrone; CI937; DUP937.;7,10-dihydroxy-2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)dibenzo[cd,g]indazol-6(2H)-one

Molecular Formula C21H25N5O4
Purity ≥95%
Solubility Soluble in DMSO, not in water
Storage 0 - 4 °C for short term, or -20 °C for long term
InChI InChI=1S/C21H25N5O4/c1-22-6-7-24-12-2-3-13-17-16(12)21(30)19-15(29)5-4-14(28)18(19)20(17)25-26(13)10-8-23-9-11-27/h2-5,22-25,27,30H,6-11H2,1H3
InChIKey QDZIHWBJFUNKOF-UHFFFAOYSA-N
SMILES CNCCNC1=C2C3=C(C=C1)N(NC3=C4C(=O)C=CC(=O)C4=C2O)CCNCCO
Reference

</br>1:A phase II study of DuP 937 (Teloxantrone) in metastatic malignant melanoma: a study of the National Cancer Institute of Canada Clinical Trials Group (NCICCTG). Shore T, Eisenhauer E, Quirt I, Belanger K, Lohmann R, Silver H, Wielgosz G.Ann Oncol. 1993 Sep;4(8):695-6. No abstract available. PMID: 8241003 </br>2:A phase II trial of DuP 937 (Teloxantrone) in non-small cell lung cancer. A study of the NCIC Clinical Trials Group. Gregg RW, Kaizer L, Fine S, Gelmon K, Wielgosz G, Eisenhauer E.Ann Oncol. 1993 Sep;4(8):693-4. No abstract available. PMID: 8241002 </br>3:Phase II study on DuP 937 (Teloxantrone) in colorectal carcinoma. A Canadian National Cancer Institute Clinical Trial Group study. Maroun JA, Skillings J, MacCormick R, Potvin M, Wielgosz G, Davidson JR, Eisenhauer E.Invest New Drugs. 1993 May-Aug;11(2-3):235-7. No abstract available. PMID: 8262739

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