Temafloxacin Hydrochloride

• CAT Number: R027004
• CAS Number: 105784-61-0
• Molecular Formula: C21H19ClF3N3O3
• Molecular Weight: 453.85
• Purity: ≥95%
• Synonyms: 1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Monohydrochloride
• Target: Antibiotic
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;hydrochloride
• InChI: InChI=1S/C21H18F3N3O3.ClH/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23;/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30);1H
• InChIKey: DDVJEYDLTXRYAJ-UHFFFAOYSA-N
• SMILES: CC1CN(CCN1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=C(C=C(C=C4)F)F)F.Cl

Temafloxacin Hydrochloride（Cat No.:R027004）is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and repair. It exhibits broad-spectrum antibacterial activity against Gram-positive and Gram-negative bacteria, making it effective for treating respiratory, urinary tract, and skin infections. Temafloxacin Hydrochloride was initially used clinically but was withdrawn due to adverse side effects, including hemolytic anemia and kidney dysfunction. Despite its clinical withdrawal, it remains a valuable research compound for studying fluoroquinolone mechanisms, bacterial resistance, and the development of safer, more effective antimicrobial agents.