Temafloxacin

• CAT Number: R063096
• CAS Number: 108319-06-8
• Molecular Formula: C21H18F3N3O3
• Molecular Weight: 417.38
• Purity: ≥95%
• Synonyms: (±)-Temafloxacin; 1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid; A 62254; A 63004; T 1258; Teflox; Temac
• Target: Bacterial
• Storage: -20°C
• IUPAC Name: 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
• InChI: InChI=1S/C21H18F3N3O3/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30)
• InChIKey: QKDHBVNJCZBTMR-UHFFFAOYSA-N
• SMILES: CC1CN(CCN1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=C(C=C(C=C4)F)F)F

Temafloxacin（Cat No.:R063096）is a fluoroquinolone antibiotic that was developed to treat bacterial infections, particularly those involving the respiratory and urinary tracts. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes crucial for bacterial DNA replication and repair. Temafloxacin exhibits a broad spectrum of activity against Gram-positive and Gram-negative bacteria, making it effective for conditions like pneumonia and complicated UTIs. However, its use was discontinued due to adverse reactions, including hemolytic anemia and renal complications, highlighting the need for careful evaluation in antibiotic development.