For research use only. Not for therapeutic Use.
Tempone-H may be used as a spin trap in chemical and biological systems to quantify peroxynitrite and superoxide radical formation. Ferric and cupric ions are effective oxidants of Tempone-H[1][2].
Using TEMPONE-H the obtained sensitivity in the detection of peroxynitrite or superoxide radicals is about 10-fold higher than using the spin traps DMPO or TMIO[1].
| Catalog Number | I043492 |
| CAS Number | 3637-11-4 |
| Synonyms | 1-hydroxy-2,2,6,6-tetramethylpiperidin-4-one |
| Molecular Formula | C9H17NO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C9H17NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h12H,5-6H2,1-4H3 |
| InChIKey | KMEUSKGEUADGET-UHFFFAOYSA-N |
| SMILES | CC1(CC(=O)CC(N1O)(C)C)C |
| Reference | [1]. Dikalov S, et al. Quantification of peroxynitrite, superoxide, and peroxyl radicals by a new spin trap hydroxylamine 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine. Biochem Biophys Res Commun. 1997 Jan 3;230(1):54-7. [2]. Dikalov SI, et al. Amyloid beta peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides. J Biol Chem. 1999 Apr 2;274(14):9392-9. |
