For research use only. Not for therapeutic Use.
Tenalisib R Enantiomer (RP6530 R Enantiomer) is an R enantiomer of Tenalisib. Tenalisib is a potent and selective PI3Kδ and PI3Kγ inhibitor with IC50 values of 25 and 33 nM, respectively[1][2].
Tenalisib, a dual PI3K δ/γ inhibitor, potentiates Ruxolitinib activity in the JAK2-V617F mutant erythroleukemia cell lines[2].
| Catalog Number | I020254 |
| CAS Number | 1639417-54-1 |
| Synonyms | 3-(3-fluorophenyl)-2-[(1R)-1-(7H-purin-6-ylamino)propyl]chromen-4-one |
| Molecular Formula | C23H18FN5O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H18FN5O2/c1-2-16(29-23-19-22(26-11-25-19)27-12-28-23)21-18(13-6-5-7-14(24)10-13)20(30)15-8-3-4-9-17(15)31-21/h3-12,16H,2H2,1H3,(H2,25,26,27,28,29)/t16-/m1/s1 |
| InChIKey | HDXDQPRPFRKGKZ-MRXNPFEDSA-N |
| SMILES | CCC(C1=C(C(=O)C2=CC=CC=C2O1)C3=CC(=CC=C3)F)NC4=NC=NC5=C4NC=N5 |
| Reference | [1]. Swaroop Vakkalanka, et al. Abstract 2704: RP6530, a dual PI3K δ/γ inhibitor, potentiates ruxolitinib activity in the JAK2-V617F mutant erythroleukemia cell lines. |
