Teneligliptin hydrobromide hydrate

• CAT Number: I018947
• CAS Number: 1572583-29-9
• Molecular Formula: C₂₂H₃₀N₆OS
• Molecular Weight: 426.58
• Purity: ≥95%
• Target: Dipeptidyl Peptidase
• IUPAC Name: [(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone;hydrate;pentahydrobromide
• InChI: InChI=1S/2C22H30N6OS.5BrH.H2O/c2*1-17-13-21(28(24-17)18-5-3-2-4-6-18)26-9-7-25(8-10-26)19-14-20(23-15-19)22(29)27-11-12-30-16-27;;;;;;/h2*2-6,13,19-20,23H,7-12,14-16H2,1H3;5*1H;1H2/t2*19-,20-;;;;;;/m00....../s1
• InChIKey: NQPRXLXVOBOTGT-KSLCDFCZSA-N
• SMILES: CC1=NN(C(=C1)N2CCN(CC2)[C@H]3C[C@H](NC3)C(=O)N4CCSC4)C5=CC=CC=C5.CC1=NN(C(=C1)N2CCN(CC2)[C@H]3C[C@H](NC3)C(=O)N4CCSC4)C5=CC=CC=C5.O.Br.Br.Br.Br.Br

Teneligliptin hydrobromide hydrate（Cat No.:I018947）is a medication used to manage type 2 diabetes. It is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4), which plays a role in breaking down incretin hormones like GLP-1 (glucagon-like peptide-1). By inhibiting DPP-4, teneligliptin increases the levels of active GLP-1, leading to enhanced insulin secretion and reduced glucagon release, thus improving blood sugar control. It is commonly prescribed as an adjunct to diet and exercise for managing hyperglycemia in diabetic patients, with a favorable safety profile and once-daily dosing.

Reference

[1]. Fukuda-Tsuru S, et al. A novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor, teneligliptin, improves postprandial hyperglycemia and dyslipidemia after single and repeated administrations. Eur J Pharmacol. 2012 Dec 5;696(1-3):194-202.