Tenofovir Alafenamide (GS-7340)

• CAT Number: A000110
• CAS Number: 379270-37-8
• Molecular Formula: C21H29N6O5P
• Molecular Weight: 476.47
• Purity: 98%
• Synonyms: GS-7340; GS 7340; UNII-EL9943AG5J
• Target: HIV
• Target Protein: P03366
• Solubility: >16.7mg/mL in DMSO
• Appearance: Solid
• Storage: Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
• IC50: 5 to 7 nM
• IUPAC Name: propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate
• InChI: InChI=1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1
• InChIKey: LDEKQSIMHVQZJK-CAQYMETFSA-N
• SMILES: C[C@H](CN1C=NC2=C(N=CN=C21)N)OC[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC3=CC=CC=C3

Tenofovir Alafenamide (GS-7340)（Cat No.:A000110）is a prodrug of tenofovir, used as part of antiretroviral therapy for HIV-1 and chronic hepatitis B infections. It is designed to deliver tenofovir more efficiently to infected cells at lower doses than its predecessor, tenofovir disoproxil fumarate (TDF), resulting in improved safety and reduced toxicity, particularly for kidney and bone health. Once inside the cells, Tenofovir Alafenamide is converted into the active form, inhibiting viral replication. Its enhanced efficacy and better safety profile make it a preferred option in long-term HIV and hepatitis B management.