Tenofovir disoproxil aspartate

• CAT Number: I009760
• CAS Number: 1571075-19-8 (aspartate)
• Molecular Formula: C23H38N7O13P
• Molecular Weight: 651.57
• Purity: ≥95%
• Synonyms: Tenofovir disoproxil aspartate; CKD-390; CKD 390; CKD390.;(R)-(((((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(oxy))bis(methylene) diisopropyl bis(carbonate) L-asparaginate
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: (2S)-2-aminobutanedioic acid;[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate
• InChI: InChI=1S/C19H30N5O10P.C4H8N2O3/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-2(4(8)9)1-3(6)7/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);2H,1,5H2,(H2,6,7)(H,8,9)/t14-;2-/m10/s1
• InChIKey: WHQLGZSDBQPTHD-KJTVYDLOSA-N
• SMILES: NC1=C2C(N(C[C@H](OCP(OCOC(OC(C)C)=O)(OCOC(OC(C)C)=O)=O)C)C=N2)=NC=N1.N[C@@H](CC(N)=O)C(O)=O

Tenofovir Disoproxil Aspartate(CAT: I009760) is a prodrug of tenofovir, an acyclic nucleotide reverse transcriptase inhibitor (NRTI) that effectively targets viral replication. By inhibiting the reverse transcriptase enzyme, it disrupts the synthesis of viral DNA, making it a cornerstone in the treatment and study of viral infections, particularly HIV and hepatitis B. The aspartate modification enhances its bioavailability and stability, making it a valuable tool for research into antiviral therapies. Tenofovir Disoproxil Aspartate is essential for exploring novel drug formulations and understanding resistance mechanisms, contributing significantly to advancements in virology and therapeutic development.