For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Tenovin-1 is a inhibitor of SIRT1 and SIRT2; activator of p21 and p53.<br>IC50 Value:<br>Target: Sirtuin<br>Tenovin-1 is a compound that belongs to the class of Tenovins, and inhibits SIRT1 and SIRT2. SIRT1 and SIRT2 are protein-deacetylases and are members of the NAD+-dependent class III histone deacetylases. Tenovin-1 has been shown to activate and elevate acetylated p53 levels, induce apoptosis in vitro.<br>in vitro: Tenovin-1 elevates the amount of p53 protein within 2 hr of treatment. This compound also increases the levels of the p53-downstream target p21CIP/WAF1 protein and mRNA, confirming that tenovin-1 can induce expression from an endogenous p53-dependent promoter [1]. Tenovin-6 inhibits the growth of S. cerevisiae cultures with an IC50 of 30 μM and is more toxic to yeast than the less water-soluble tenovin-1.<br>in vivo: Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts [1].<br></p>
| Catalog Number | I003395 |
| CAS Number | 380315-80-0 |
| Synonyms | N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide |
| Molecular Formula | C₂₀H₂₃N₃O₂S |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Solubility | Soluble to 25 mM in DMSO |
| Storage | 3 years -20C powder |
| InChI | InChI=1S/C20H23N3O2S/c1-13(24)21-16-9-11-17(12-10-16)22-19(26)23-18(25)14-5-7-15(8-6-14)20(2,3)4/h5-12H,1-4H3,(H,21,24)(H2,22,23,25,26) |
| InChIKey | WOWJIWFCOPZFGV-UHFFFAOYSA-N |
| SMILES | CC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C |
| Reference | <p style=/line-height:25px/> |
