Tenovin-1

• CAT Number: I003395
• CAS Number: 380315-80-0
• Molecular Formula: C₂₀H₂₃N₃O₂S
• Molecular Weight: 369.48
• Purity: ≥95%
• Synonyms: N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
• Target: Metabolic Enzyme/Protease
• Solubility: Soluble to 25 mM in DMSO
• Storage: 3 years -20C powder
• InChI: InChI=1S/C20H23N3O2S/c1-13(24)21-16-9-11-17(12-10-16)22-19(26)23-18(25)14-5-7-15(8-6-14)20(2,3)4/h5-12H,1-4H3,(H,21,24)(H2,22,23,25,26)
• InChIKey: WOWJIWFCOPZFGV-UHFFFAOYSA-N
• SMILES: CC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C

Tenovin-1（Cat No.:I003395）is a small molecule compound that acts as an inhibitor of the sirtuin family of proteins, specifically SIRT1 and SIRT2. These proteins are involved in regulating cellular processes like aging, DNA repair, and metabolism. By inhibiting SIRT1 and SIRT2, Tenovin-1 has been shown to induce cell cycle arrest and apoptosis in cancer cells, making it a potential anticancer agent. It also activates p53, a tumor suppressor protein, enhancing its role in cell survival and DNA damage response. Tenovin-1 has been studied for its potential in treating various cancers and age-related diseases.

Reference

[1]. Lain S, Hollick JJ, Campbell J, Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63.