For research use only. Not for therapeutic Use.
Tenovin 6 Hydrochloride (Cat No.: I000116) is a small molecule compound that has garnered attention in cancer research. It functions as a SIRT1/2 (sirtuin) activator and inhibitor of histone deacetylases (HDACs). By modulating these pathways, Tenovin 6 Hydrochloride can influence cellular processes such as aging, DNA repair, and apoptosis. Its potential therapeutic applications are being explored in the context of cancer treatment and age-related diseases. Early studies suggest it may enhance the effects of chemotherapy and promote tumor cell death.
| Catalog Number | I000116 |
| CAS Number | 1011301-29-3 |
| Molecular Formula | C25H35ClN4O2S |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Solubility | DMSO: ≥ 49 mg/mL |
| Storage | Store at -20°C |
| IC50 | 21 uM (human SIRT1); 10 uM (human SIRT2) |
| IUPAC Name | 4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide;hydrochloride |
| InChI | 1S/C25H34N4O2S.ClH/c1-25(2,3)19-11-9-18(10-12-19)23(31)28-24(32)27-21-15-13-20(14-16-21)26-22(30)8-6-7-17-29(4)5;/h9-16H,6-8,17H2,1-5H3,(H,26,30)(H2,27,28,31,32);1H |
| InChIKey | UBNCTIDXQDCEPI-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C.Cl |
| Reference | [1]. Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. |
