Tenovin-6

• CAT Number: I000118
• CAS Number: 1011557-82-6
• Molecular Formula: C25H34N4O2S
• Molecular Weight: 454.63
• Purity: ≥95%
• Synonyms: 4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide
• Target: Metabolic Enzyme/Protease
• Solubility: DMSO 20 mg/ml; Ethanol 1 mg/ml
• Storage: Store at -20° C
• IC50: 21 uM (human SIRT1); 10 uM (human SIRT2)
• InChI: InChI=1S/C25H34N4O2S/c1-25(2,3)19-11-9-18(10-12-19)23(31)28-24(32)27-21-15-13-20(14-16-21)26-22(30)8-6-7-17-29(4)5/h9-16H,6-8,17H2,1-5H3,(H,26,30)(H2,27,28,31,32)
• InChIKey: BVJSXSQRIUSRCO-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C

Tenovin-6(CAT; I000118) is a potent and selective small-molecule inhibitor of sirtuins, specifically SIRT1 and SIRT2, with additional activity against p53-activating pathways. This compound is widely used in research exploring the regulation of cellular processes such as apoptosis, DNA repair, and metabolism. By inhibiting sirtuin deacetylase activity, Tenovin-6 promotes acetylation of p53, enhancing its tumor-suppressor function, making it valuable in cancer research and studies on aging and neurodegenerative diseases. Its high purity and consistency ensure reliable results, supporting investigations into sirtuin-mediated pathways and therapeutic strategies targeting epigenetic regulation.