Tenoxicam

• CAT Number: A000453
• CAS Number: 59804-37-4
• Molecular Formula: C13H11N3O4S2
• Molecular Weight: 337.4
• Purity: ≥95%
• Synonyms: 59804-37-4; Mobiflex; Tilcotil; Tenoxicamum; Tenoxicamum [INN-Latin]
• Target: COX
• Storage: -20°C
• InChI: 1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
• InChIKey: LZNWYQJJBLGYLT-UHFFFAOYSA-N
• SMILES: CN1C(=C(C2=C(S1(=O)=O)C=CS2)O)C(=O)NC3=CC=CC=N3

Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID). It was originated by Roche but as of 2008 is sold by Meda AB under the trade name Mobiflex.

Reference

1: Chen SH, Chen SS, Chang CT, Huang CH, Fan SZ, Chen LK. The use of tenoxicam to
prevent symptoms of discomfort induced by vagotonia during uterus manipulation in
cesarean sections. Medicine (Baltimore). 2017 Jul;96(30):e7624. doi:
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2: Sargin MA, Yassa M, Celik A, Ergun E, Tug N. Lidocaine and tenoxicam
effectiveness for pain relief during Pipelle: Non-randomised double-blind
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3: Elkomy MH, El Menshawe SF, Eid HM, Ali AM. Development of a nanogel
formulation for transdermal delivery of tenoxicam: a
pharmacokinetic-pharmacodynamic modeling approach for quantitative prediction of
skin absorption. Drug Dev Ind Pharm. 2017 Apr;43(4):531-544. doi:
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4: Kaplan V, Eroğlu CN. Comparison of the Effects of Daily Single-Dose Use of
Flurbiprofen, Diclofenac Sodium, and Tenoxicam on Postoperative Pain, Swelling,
and Trismus: A Randomized Double-Blind Study. J Oral Maxillofac Surg. 2016
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5: Sanel S, Arpaz O, Unay K, Turkmen I, Simsek S, Ugutmen E. Comparison of
intra-articular bupivacaine-morphine with bupivacaine-tenoxicam combinations on
post-operative analgesia in patients with arthroscopic meniscectomy: a
prospective, randomised study. Int Orthop. 2016 Mar;40(3):601-5. doi:
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6: Erbas M, Simsek T, Kiraz HA, Sahin H, Toman H. [Comparison of the effectivity
of oral and intra-articular administration of tenoxicam in patients with knee
osteoarthritis]. Rev Bras Anestesiol. 2015 Sep-Oct;65(5):333-7. doi:
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7: Ozsoy Z, Kayaoglu HA, Ozkan N, Ozsoy S, Yaylak F, Yenidogan E. The effect of
methylprednisolone and tenoxicam on the protection of damage of the nerve
physiomorphology caused by prolene mesh. Int J Surg. 2015 Oct;22:159-63. doi:
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8: Erbas M, Simsek T, Kiraz HA, Sahin H, Toman H. Comparison of the effectivity
of oral and intra-articular administration of tenoxicam in patients with knee
osteoarthritis. Braz J Anesthesiol. 2015 Sep-Oct;65(5):333-7. doi:
10.1016/j.bjane.2013.12.003. Epub 2014 Feb 6. PubMed PMID: 26323729.

9: Orak MM, Ak D, Midi A, Laçin B, Purisa S, Bulut G. Comparison of the effects
of chronic intra-articular administration of tenoxicam, diclofenac, and
methylprednisolone in healthy rats. Acta Orthop Traumatol Turc.
2015;49(4):438-46. doi: 10.3944/AOTT.2015.14.0312. PubMed PMID: 26312474.

10: Goindi S, Narula M, Kalra A. Microemulsion-Based Topical Hydrogels of
Tenoxicam for Treatment of Arthritis. AAPS PharmSciTech. 2016 Jun;17(3):597-606.
doi: 10.1208/s12249-015-0383-0. Epub 2015 Aug 19. PubMed PMID: 26285672.