For research use only. Not for therapeutic Use.
Tenuifolin is effective and has a protective action. Tenuifolin inhibits β-secretase decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin’s ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin’s potential for use in urinary disease (AD).
Tenuifolin (50 μM; 24 h) protects SH-SY5Y cells against Aβ25-35 (20 μM)-induced apoptosis, and decreased the mRNA level of caspase-3 and -9[2].Tenuifolin (50 μM, 100 μM; 24 h) inhibits Aβ25-35 (20 μM)-induced the loss of mitochondria-membrane potential in SH-SY5Y cells[2].
Tenuifolin (20-80 mg/kg; po; single dose) induces beneficial effects on learning and memory, prevents loss and apoptosis of neurons in APP/PS1 mice[2].
| Catalog Number | R025088 |
| CAS Number | 20183-47-5 |
| Synonyms | (2S,3R,4S,4aR,6aR,6bR,8aS,12aS,14aR,14bR)-2-hydroxy-6b-(hydroxymethyl)-4,6a,11,11,14b-pentamethyl-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-4,8a-dicarboxylic acid |
| Molecular Formula | C36H56O12 |
| Purity | ≥95% |
| InChI | InChI=1S/C36H56O12/c1-31(2)10-11-35(30(45)46)12-13-36(17-38)18(19(35)14-31)6-7-22-32(3)15-20(39)27(34(5,29(43)44)23(32)8-9-33(22,36)4)48-28-26(42)25(41)24(40)21(16-37)47-28/h6,19-28,37-42H,7-17H2,1-5H3,(H,43,44)(H,45,46)/t19-,20-,21+,22+,23+,24+,25-,26+,27-,28-,32+,33+,34-,35-,36-/m0/s1 |
| InChIKey | DBJLNNAUDGIUAE-YGIRLYIESA-N |
| SMILES | CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)C(=O)O)OC6C(C(C(C(O6)CO)O)O)O)O)C)C)C2C1)CO)C(=O)O)C |
| Reference | [1]. Ki-Yeol Yoo, et al. Terpenoids as Potential Anti-Alzheimer’s Disease Therapeutics. Molecules 2012, 17(3), 3524-3538 |
