Teprasiran sodium

• CAT Number: I040024
• CAS Number: 2169310-72-7
• Molecular Formula: C380H448O262N140P36Na36
• Molecular Weight: 13111.07
• Purity: ≥95%

Teprasiran Sodium (Cat No.: I040024) is a small interfering RNA (siRNA) therapeutic that targets p53 to prevent acute kidney injury (AKI) following ischemic or surgical stress. By transiently silencing p53 expression, it reduces apoptosis and inflammation in renal tissues, protecting against kidney damage. It is being explored for clinical applications in preventing AKI after cardiac surgery or transplantation. The sodium salt form enhances solubility and stability for in vivo applications, making Teprasiran a promising candidate in nephrology and renal disease research.

Reference

[1]. Matthias Thielmann, et al. Teprasiran, a Small Interfering RNA, for the Prevention of Acute Kidney Injury in High-Risk Patients Undergoing Cardiac Surgery: A Randomized Clinical Study. Circulation. 2021;144:1133-1144.