For research use only. Not for therapeutic Use.
Terbutaline is an orally active β2-adrenergic receptor agonist and an active metabolite of bambuterol[1]. Terbutaline can be used in asthma symptom research[2].
Terbutaline (0-10 μM, 1 hour) enhances MKP-1 expression in activated mouse macrophages[3].
Terbutaline (intraperitoneal injection; 0.5 mg/kg; twice a day; 20 days) treatment can improve the allodynia in ob/ob mice[4].
| Catalog Number | I009466 |
| CAS Number | 23031-25-6 |
| Synonyms | 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol |
| Molecular Formula | C12H19NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H19NO3/c1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8/h4-6,11,13-16H,7H2,1-3H3 |
| InChIKey | XWTYSIMOBUGWOL-UHFFFAOYSA-N |
| SMILES | CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O |
| Reference | [1]. Mohamed Ismail NA, et al. Nifedipine versus terbutaline for tocolysis in external cephalic version. Int J Gynaecol Obstet. 2008 Sep;102(3):263-6. [2]. Joana A Loureiro, et al. The interaction of a β2 adrenoceptor agonist drug with biomimetic cell membrane models: The case of terbutaline sulphate. Life Sci. 2021 Nov 15;285:119992. [3]. Tiina Keränen, et al. Anti-Inflammatory Effects of β2-Receptor Agonists Salbutamol and Terbutaline Are Mediated by MKP-1. PLoS One. 2016 Feb 5;11(2):e0148144. [4]. Nada Choucair-Jaafar, et al. The antiallodynic action of nortriptyline and terbutaline is mediated by β(2) adrenoceptors and δ opioid receptors in the ob/ob model of diabetic polyneuropathy. Brain Res. 2014 Feb 10;1546:18-26. |
