For research use only. Not for therapeutic Use.
Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC50 of 30 µM. Teriflunomide impurity 3 is less active against COX-2 (IC50>100 µM)[1].
Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide; compound 11q) is an amide-bond-reversed compound bearing trifluoromethyl and amino substituents showed potent COX-1-selective inhibitory activity[1].
| Catalog Number | I044545 |
| CAS Number | 1011244-72-6 |
| Synonyms | 4-amino-N-[4-(trifluoromethyl)phenyl]benzamide |
| Molecular Formula | C14H11F3N2O |
| Purity | ≥95% |
| InChI | InChI=1S/C14H11F3N2O/c15-14(16,17)10-3-7-12(8-4-10)19-13(20)9-1-5-11(18)6-2-9/h1-8H,18H2,(H,19,20) |
| InChIKey | YUWBBWHECQSIKL-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C(=O)NC2=CC=C(C=C2)C(F)(F)F)N |
| Reference | [1]. Hiroki Kakuta, et al. Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor. J Med Chem. 2008 Apr 24 |
