tert-Butyl 11-aminoundecanoate

• CAT Number: I017370
• CAS Number: 220851-29-6
• Molecular Formula: C15H31NO2
• Molecular Weight: 257.41
• Purity: ≥95%
• Synonyms: tert-butyl 11-aminoundecanoate
• InChI: InChI=1S/C15H31NO2/c1-15(2,3)18-14(17)12-10-8-6-4-5-7-9-11-13-16/h4-13,16H2,1-3H3
• InChIKey: LEMMJNALIIDDRY-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCCCCCCCCCN

tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker, which refers to the PEG composition. tert-Butyl 11-aminoundecanoate can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera. Sci Rep. 2019 Dec 23;9(1):19654.
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