Tesirine intermediate-2

• CAT Number: I040670
• CAS Number: 1430738-34-3
• Molecular Formula: C40H55N5O10Si
• Molecular Weight: 793.98
• Purity: ≥95%
• Synonyms: [4-[[(2S)-2-[[(2S)-3-methyl-2-(prop-2-enoxycarbonylamino)butanoyl]amino]propanoyl]amino]phenyl]methyl (6S,6aS)-6-[tert-butyl(dimethyl)silyl]oxy-3-hydroxy-2-methoxy-8-methyl-11-oxo-6a,7-dihydro-6H-pyrrolo[2,1-c][1,4]benzodiazepine-5-carboxylate
• InChI: InChI=1S/C40H55N5O10Si/c1-12-17-53-38(50)43-33(23(2)3)35(48)41-25(5)34(47)42-27-15-13-26(14-16-27)22-54-39(51)45-29-20-31(46)32(52-9)19-28(29)36(49)44-21-24(4)18-30(44)37(45)55-56(10,11)40(6,7)8/h12-16,19-21,23,25,30,33,37,46H,1,17-18,22H2,2-11H3,(H,41,48)(H,42,47)(H,43,50)/t25-,30-,33-,37-/m0/s1
• InChIKey: XKNXDIGKRXQNKC-AGUYGVQZSA-N
• SMILES: CC1=CN2C(C1)C(N(C3=CC(=C(C=C3C2=O)OC)O)C(=O)OCC4=CC=C(C=C4)NC(=O)C(C)NC(=O)C(C(C)C)NC(=O)OCC=C)O[Si](C)(C)C(C)(C)C

Tesirine Intermediate-2(CAT: I040670) is a crucial building block in the synthesis of Tesirine, a DNA cross-linking cytotoxic payload used in antibody-drug conjugates (ADCs). This intermediate contributes to the assembly of the pyrrolobenzodiazepine (PBD) dimer core or the functional linker region, both essential for Tesirine’s potent antitumor activity and targeted delivery. Tesirine Intermediate-2 is structurally optimized for high reactivity and compatibility with bioconjugation techniques, enabling efficient coupling to antibody-linker systems. It supports the development of next-generation ADCs by ensuring precision, stability, and effective drug release within the tumor microenvironment. Ideal for oncology research and targeted drug synthesis.