Tetrabenazine Racemate

• CAT Number: I004682
• CAS Number: 718635-93-9
• Molecular Formula: C19H27NO3
• Molecular Weight: 317.429
• Purity: ≥95%
• Target: Monoamine Transporter
• Solubility: DMSO: ≥ 3.1 mg/mL
• Storage: 3 years -20C powder
• IUPAC Name: 9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one
• InChI: InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3
• InChIKey: MKJIEFSOBYUXJB-UHFFFAOYSA-N
• SMILES: CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC

Tetrabenazine (Racemate) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2).(1) The reference for administration is 0.25-0.75 mg/kg IP(2) Injections of tetrabenazine into accumbens core also reduced FR5 lever pressing and increased chow intake.(3) Tetrabenazine (Racemate) reduced extracellular DA and altered DARPP-32 signaling in both substance-P- and enkephalin-containing accumbens neurons.(4) Tetrabenazine (Racemate) inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice.

Reference

[1]. Nunes EJ et al. Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression. J Neurosci. 2013 Dec 4;33(49):19120-30.
[2]. Podurgiel SJ et al. The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: implications for pharmacological models of parkinsonian tremor. Neuroscience. 2013 Oct 10;250:507-19.
[3]. Reches A et al. Tetrabenazine, an amine-depleting drug, also blocks dopamine receptors in rat brain. J Pharmacol Exp Ther. 1983 Jun;225(3):515-21.